Structural dynamic modification

Twenty Years of Structural Dynamic Modification – A Review

Structural dynamic modification techniques have been available as a design tool for several decades. This article reviews the methodology of the technique including both proportional and complex mode formulations. Issues pertaining to limitations on their use and truncation effects of unmeasured modes are discussed. Also discussed is the use of simplistic elements through higher order elements....

Dynamic Modification of Workflows

The aim of this report is twofold, to present the issues and challenges related to workflow modification, and to lay the foundation for a comprehensive framework to support Dynamic Workflows. We identify various classes of workflow modification in relation to business process change, and based on this classification, we present a three-phase modification methodology that allows effective handli...

Dynamic Kernel Modification and Extensibility

Dynamic Modification of Continuous Queries

Nowadays, sophisticated near-real time data stream queries run on massive and continuous amount of data, resulting from transactions and measurements. However, these Long-Running Data Stream Queries might not correspond to user requirements at some point and need to be modified. Considering the distributed, continuous and near-real time nature of data streams, modifying a query needs to be cond...

Development and Structural Modification of BACE1 Inhibitors.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder which usually occurs in the elderly. The accumulation of β-amyloid and the formation of neurofibrillary tangles are considered as the main pathogenies of AD. Research suggests that β-secretase 1 (BACE1) plays an important role in the formation of β-amyloid. Discovery of new BACE1 inhibitors has become a significant method to s...